TS also demonstrates strong few-shot and prompt capabilities when applied to new domains and tasks.

Astronauts aboard the International Space Station (ISS) had slower memory, attention and processing speed after six months, raising concerns about the impact of cognitive impairment on future space missions to Mars. The extreme environment of space, with reduced gravity, harsh radiation and the lack of regular sunrises and sunsets, can have dramatic effects on astronaut health, from muscle loss to an increased risk of heart disease. However, the cognitive effects of long-term space travel are less well documented. Inside NASA's ambitious plan to bring the ISS crashing back to Earth Now, Sheena Dev at NASA's Johnson Space Center in Houston, Texas, and her colleagues have looked at the cognitive performance of 25 astronauts during their time on the ISS. The team ran the astronauts through 10 tests, some of which were done on Earth, once before and twice after the mission, while others were done on the ISS, both early and later in the mission.

There is a long history of research into time series clustering using distance-based partitional clustering. Many of the most popular algorithms adapt k-means (also known as Lloyd's algorithm) to exploit time dependencies in the data by specifying a time series distance function. However, these algorithms are often presented with k-means configured in various ways, altering key parameters such as the initialisation strategy. This variability makes it difficult to compare studies because k-means is known to be highly sensitive to its configuration. To address this, we propose a standard Lloyd's-based model for TSCL that adopts an end-to-end approach, incorporating a specialised distance function not only in the assignment step but also in the initialisation and stopping criteria. By doing so, we create a unified structure for comparing seven popular Lloyd's-based TSCL algorithms. This common framework enables us to more easily attribute differences in clustering performance to the distance function itself, rather than variations in the k-means configuration.

Over the last three to five years, it has become possible to generate machine learning synthetic data for healthcare-related uses. However, concerns have been raised about potential negative factors associated with the possibilities of artificial dataset generation. These include the potential misuse of generative artificial intelligence (AI) in fields such as cybercrime, the use of deepfakes and fake news to deceive or manipulate, and displacement of human jobs across various market sectors. Here, we consider both current and future positive advances and possibilities with synthetic datasets. Synthetic data offers significant benefits, particularly in data privacy, research, in balancing datasets and reducing bias in machine learning models. Generative AI is an artificial intelligence genre capable of creating text, images, video or other data using generative models. The recent explosion of interest in GenAI was heralded by the invention and speedy move to use of large language models (LLM). These computational models are able to achieve general-purpose language generation and other natural language processing tasks and are based on transformer architectures, which made an evolutionary leap from previous neural network architectures. Fuelled by the advent of improved GenAI techniques and wide scale usage, this is surely the time to consider how synthetic data can be used to advance infectious disease research. In this commentary we aim to create an overview of the current and future position of synthetic data in infectious disease research.

Advances in time series models are driving a shift from conventional deep learning methods to pre-trained foundational models. While pre-trained transformers and reprogrammed text-based LLMs report state-of-the-art results, the best-performing architectures vary significantly across tasks, and models often have limited scope, such as focusing only on time series forecasting. Models that unify predictive and generative time series tasks under a single framework remain challenging to achieve. We introduce UniTS, a multi-task time series model that uses task tokenization to express predictive and generative tasks within a single model. UniTS leverages a modified transformer block designed to obtain universal time series representations. This design induces transferability from a heterogeneous, multi-domain pre-training dataset-often with diverse dynamic patterns, sampling rates, and temporal scales-to many downstream datasets, which can also be diverse in task specifications and data domains. Across 38 datasets spanning human activity sensors, healthcare, engineering, and finance domains, UniTS model performs favorably against 12 forecasting models, 20 classification models, 18 anomaly detection models, and 16 imputation models, including repurposed text-based LLMs. UniTS demonstrates effective few-shot and prompt learning capabilities when evaluated on new data domains and tasks. In the conventional single-task setting, UniTS outperforms strong task-specialized time series models. The source code and datasets are available at https://github.com/mims-harvard/UniTS.

This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how to design LLM-based automation tools and how to robustly evaluate their performance. During the 2023 Evidence Synthesis Hackathon we conducted two feasibility studies. Firstly, to automatically extract study characteristics from human clinical, animal, and social science domain studies. We used two studies from each category for prompt-development; and ten for evaluation. Secondly, we used the LLM to predict Participants, Interventions, Controls and Outcomes (PICOs) labelled within 100 abstracts in the EBM-NLP dataset. Overall, results indicated an accuracy of around 80%, with some variability between domains (82% for human clinical, 80% for animal, and 72% for studies of human social sciences). Causal inference methods and study design were the data extraction items with the most errors. In the PICO study, participants and intervention/control showed high accuracy (>80%), outcomes were more challenging. Evaluation was done manually; scoring methods such as BLEU and ROUGE showed limited value. We observed variability in the LLMs predictions and changes in response quality. This paper presents a template for future evaluations of LLMs in the context of data extraction for systematic review automation. Our results show that there might be value in using LLMs, for example as second or third reviewers. However, caution is advised when integrating models such as GPT-4 into tools. Further research on stability and reliability in practical settings is warranted for each type of data that is processed by the LLM.

Computer games are widespread nowadays and enjoyed by people of all ages. But when it comes to kids, playing these games can be more than just fun, it is a way for them to develop important skills and build emotional intelligence. Facial expressions and sounds that kids produce during gameplay reflect their feelings, thoughts, and moods. In this paper, we propose a novel framework that integrates a fuzzy approach for the recognition of emotions through the analysis of audio and video data. Our focus lies within the specific context of computer games tailored for children, aiming to enhance their overall user experience. We use the FER dataset to detect facial emotions in video frames recorded from the screen during the game. For the audio emotion recognition of sounds a kid produces during the game, we use CREMA-D, TESS, RAVDESS, and Savee datasets. Next, a fuzzy inference system is used for the fusion of results. Besides this, our system can detect emotion stability and emotion diversity during gameplay, which, together with prevailing emotion report, can serve as valuable information for parents worrying about the effect of certain games on their kids. The proposed approach has shown promising results in the preliminary experiments we conducted, involving 3 different video games, namely fighting, racing, and logic games, and providing emotion-tracking results for kids in each game. Our study can contribute to the advancement of child-oriented game development, which is not only engaging but also accounts for children's cognitive and emotional states.

Time Series Classification (TSC) is an extensively researched field from which a broad range of real-world problems can be addressed obtaining excellent results. One sort of the approaches performing well are the so-called dictionary-based techniques. The Temporal Dictionary Ensemble (TDE) is the current state-of-the-art dictionary-based TSC approach. In many TSC problems we find a natural ordering in the labels associated with the time series. This characteristic is referred to as ordinality, and can be exploited to improve the methods performance. The area dealing with ordinal time series is the Time Series Ordinal Classification (TSOC) field, which is yet unexplored. In this work, we present an ordinal adaptation of the TDE algorithm, known as ordinal TDE (O-TDE). For this, a comprehensive comparison using a set of 18 TSOC problems is performed. Experiments conducted show the improvement achieved by the ordinal dictionary-based approach in comparison to four other existing nominal dictionary-based techniques.

Time series clustering is the act of grouping time series data without recourse to a label. Algorithms that cluster time series can be classified into two groups: those that employ a time series specific distance measure; and those that derive features from time series. Both approaches usually rely on traditional clustering algorithms such as $k$-means. Our focus is on distance based time series that employ elastic distance measures, i.e. distances that perform some kind of realignment whilst measuring distance. We describe nine commonly used elastic distance measures and compare their performance with k-means and k-medoids clustering. Our findings are surprising. The most popular technique, dynamic time warping (DTW), performs worse than Euclidean distance with k-means, and even when tuned, is no better. Using k-medoids rather than k-means improved the clusterings for all nine distance measures. DTW is not significantly better than Euclidean distance with k-medoids. Generally, distance measures that employ editing in conjunction with warping perform better, and one distance measure, the move-split-merge (MSM) method, is the best performing measure of this study. We also compare to clustering with DTW using barycentre averaging (DBA). We find that DBA does improve DTW k-means, but that the standard DBA is still worse than using MSM. Our conclusion is to recommend MSM with k-medoids as the benchmark algorithm for clustering time series with elastic distance measures. We provide implementations in the aeon toolkit, results and guidance on reproducing results on the associated GitHub repository.